核斑点凝聚促进T细胞活化的机制研究

RNA binding protein Pcbp1 maintains mitochondria integrity to promote antibody production and germinal center response

Single-cell and spatial transcriptomics reveals memory CD8+ T cell differentiation fostered by monocytes through membrane-bound TGF-β

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development

Rack1 regulates B-cell development and function by binding to and stabilizing transcription factor Pax5

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

Thymic MSCs-adipocytes directional differentiation mediated by MRAP contributes to the process of thymic involution

Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis

Resolving inflammation: the checkpoint in RORγt+ T cells

The pathogenic polarization of stem-like Th2 cells

ATG5抑制甲硫氨酸代谢促进记忆 CD8+T细胞分化增强肝癌免疫治疗疗效的机制研究

FTO mediated-m6A methylation controls effector CD8+ T cells differrentiation during adaptive immune response.

SUMOylation of ribonucleotide reductase decides the pathogenicity of Alphaherpesvirus

Siglec-G suppresses CD8+ T cells responses through metabolic rewiring and can be targeted to enhance tumor immunotherapy

TIM-3 restrains antiviral and antitumor immunity by regulating CD8+ T cell memory

Succinate suppresses α-KG through IDH2 succinylation regulating differentiation of hematopoietic stem cell

新型NEK7共价抑制剂用于NLRP3炎症小体驱动的代谢性疾病治疗

Dual role of RNA-binding protein DHX9 in antiviral innate immunity and inflammatory bowel disease

Regulation of Cytokine Receptor Trafficking in Innate Immunity and Inflammation

Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models

肝脏内皮细胞通过YAP/TEAD1-CXCL17通路募集外周MDSC抗肝脏缺血再灌注损伤

Aberrant Differentiation and Expansion of Lymphoid Cells and Myeloid Cells in Severe COVID-19 and Long COVID

ERMAP affects T cell function by regulating dendritic cell maturation and differentiation to improve EAE

Neddylation of the central adaptor protein ASC activates the inflammasome

Lithium carbonate induces myofibroblast necroptosis to reverse pulmonary fibrosis

RNA结合的E3泛素连接酶MKRN2通过抑制IL-6翻译抑制炎症反应

Cholinergic macrophages promote the resolution of peritoneal inflammation

Chit1 improves the innate immune defect of macrophages caused by kidney injury during aging through regulating the TFEB-mediated autophagy-lysosome pathway

Tim-4 maintains colonic homeostasis by regulating macrophage trafficing via LKB1-AMPK-NF-kB axis

基于卷积神经网络模型筛选新型抗胰腺癌小分子化合物Co68

应激条件下线粒体编码肽MOTS-c通过自反馈保护机制缓解炎症反应损伤

NLRP3的犹素化修饰通过抑制其自噬降解维持NLRP3炎症小体激活

Cellular spermine and the derivative SD1 restrain cytokine-mediated inflammation and autoimmunity by targeting JAK signaling

靶向Menin调控Treg分化及改善炎症性肠病的作用研究

Oral nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance

APOE deficiency enhanced granulocytic myeloid-derived suppressor cells through ER stress-STAT5 axis

牛病毒性腹泻病毒感染诱导自噬抑制I型干扰素反应促进病毒复制的分子机制研究

Activation/inactivation of Tregs mediated by Kv1.3 potassium channels synergistically with exosome secretion to regulate myocardial fibrosis

CD8免疫调节性新亚群的鉴定以及在造血干细胞移植后缓解GVHD的调控机制研究

The mechanism of rapamycin in the treatment of severe influenza

HSPB1诱导线粒体自噬抑制肝癌细胞对索拉菲尼敏感性

Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model

CDKN3驱动类风湿关节炎Treg炎性衰老的作用和机制

Protein phosphatase 2A promotes CD8+ T cell effector function through the augment of CD28 co-stimulation.

循环细胞外囊泡通过调控肾脏炎症反应参与糖尿病肾病的作用初探

AIM2 Dampens the Homeostasis of Murine Inhibitory CD8+ Regulatory T cells

ASB17 maintains immune homeostasis by suppressing NLRP3 inflammasome activation in dendritic cells

Impact of Gut Microbiota and Their Metabolites on T Cell Function: Implications for Antitumor Immunity and Viral Clearance

肝脏糖原合成通过 UDPG 阻断 S1P，从而拮抗脂肪生成

ACSL5介导的反式油酸代谢增强肿瘤抗原提呈和免疫治疗

Rbm17 modulates taurocholic acid and free fatty acid metabolism to drive immune suppression microenvironment promoting hepatocellular carcinoma progression

IL-37d通过非TCS2依赖的方式抑制Rheb-mTORC1轴以缓解酒精性肝病

Tumor ABCC4-mediated release of PGE2 induces CD8+ T cell dysfunction and impairs PD-1 blockade in prostate cancer

TREM2-mediated cholesterol metabolism in macrophages prevents anti-tumor immunity

PIK3CD获功能突变通过影响线粒体稳态导致T细胞衰老的机制研究

肿瘤相关脂肪细胞调控CD8+T细胞脂代谢介导其功能耗竭

转酮醇酶介导的非氧化磷酸戊糖途径通过代谢、表观遗传学和信号转导的综合调控驱动巨噬细胞介导的炎症反应

Palmitic acid from liver cancer mediated SMAD2 palmitoylation promotes Treg cells differentiation

Interleukin-1-IRF1 reprograms epithelial lipid metabolism to induce type I interferons-independent antiviral response

GSDMD-mediated metabolic crosstalk promotes tissue repair

空间多组学解析MASH相关肝癌炎癌转化的机制研究

Targeting the mevalonate pathway-dependent geranylgeranylation of RAB proteins attenuates systemic lupus erythematosus through eliminating antibody-secreting cells and inhibiting B cell proliferation and survival

信号调节蛋白α减少通过促进PKM2核转位加重糖尿病肾病过程中足细胞损伤

血管生成相关lncRNAs在肺腺癌免疫微环境和预后中的作用

The Toxoplasma effector GRA4 hijacks host TBK1 to oppositely regulate anti-T. gondii immunity and tumor immunotherapy

RNA m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil response

A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

TRIM50 negatively regulates antibacterial immunity by targeting NOD2 for ubiquitination

TOR3A在抗RSV先天免疫中的作用和机制研究

Mitophagy mediated by infectious bronchitis virus N protein inhibits innate immune response by degrading ILF3

Helicobacter pylori activates mast cells to promote gastric inflammation via HIF-1α-GPR171-MCP-1 pathway

Macrophages hijack carbapenem-resistance hypervirulent K.pneumoniae by blocking SLC7A11-manipulatived iron stress

High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases

幽门螺杆菌感染对类风湿关节炎进展的机制研究

Neuropilin-1high单核细胞在预防新生儿炎症中作用机制研究

Alveolar epithelial cells shape lipopolysaccharide-induced inflammatory responses and reprogramming of alveolar macrophages

Long-lasting humoral and cellular memory immunity to vaccinia virus Tiantan provides pre-existing immunity against mpox virus in Chinese population

通过旁观者通路激活的GNLY+CD8+T细胞是PLWH早衰及持续高炎症水平的关键因素

猪繁殖与呼吸综合征病毒利用 MALT1 调控自噬流切换病毒释放和贮存

African swine fever virus pI73R antagonizes stress granule assembly by suppressing PKR activation and sequestering RNA

Radiation facilitates DNA mismatch repair heterogeneous tumors promotes immune surveillance

肿瘤诱导新型肺上皮细胞功能“极化”促进转移微环境形成的机制研究

HBV相关肝癌分泌HDAC2-AS2拮抗T细胞CDK9免疫逃逸机制研究

The Optimal Timing of Anti-PD-1 Antibody Combined with Chemotherapy Administration in NSCLC Patients

The regulatory mechanism of bona fide neoantigen-specific CD8+ T cells in antitumor immunity

PRTN3 suppresses cytotoxic immune-cell activation and antitumoral immunity through proteolytic cleavage of CXCL9 in KRAS mutant lung adenocarcinoma

FAP+ Gastric cancer mesenchymal stromal cells via paracrining INHBA and remodeling ECM promote tumor progression

YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer

Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

CD300ld驱动肿瘤中性粒细胞免疫抑制状态转变的机制研究

RNA-binding Protein ZCCHC4 Promotes Hepatocellular Carcinoma Chemoresistance and immune evasion by Disrupting DNA Damage-Induced Apoptosis

Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

早期肿瘤编辑机制及其在肿瘤免疫治疗中的潜在应用

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis

PID1抑制LRP1膜转位调控巨噬细胞胞葬重塑HCC肿瘤免疫微环境机制研究

CD7-CAR-T细胞治疗的基础与转化研究

基于CD146的新型CAR 分子平台设计及实体瘤治疗

Fungi metabolites specifically inhibit tumor progression by converting pro-tumor macrophages

CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8+ T cells in mice

XCL1–secreting CEA CAR-T cells promote generation of the endogenous CD8+ T cells against tumor neoantigens to confer a long-term anti-tumor immunity

Effective production of highly functional CAR-macrophages from human pluripotent stem cells for cancer immunotherapy

CCL5-driven Swarming Enhances CAR T Cell Efficacy in Solid Tumors

Genetically Engineered Tumor-derived exosomes regulate the immune microenvironment and intestinal flora to ameliorate the progression of colorectal cancer

脂质转运蛋白MFSD2A在抗肿瘤免疫中的作用

Tumor stroma regulation by lysyl oxidase for enhancing antibody- drug conjugate therapy performance in pancreatic cancer

Unrevealing the therapeutic role of Z18: a target of natural killer cell anti-tumor immunity

肝癌瘤内菌诱导ILC2细胞分泌LTα驱动三级淋巴结构形成增强肝癌免疫治疗疗效的机制研究

EZH2抑制剂通过调节肿瘤微环境中巨噬细胞极化抑制结直肠癌

免疫触发在嵌合抗原受体设计中的应用

Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression

新型免疫佐剂OP-D 通过激活 STING有效增强PD-1抗体的抗肿瘤疗效

自身DNA适应性免疫

系统性红斑狼疮患者自身反应性抗体的克隆及功能鉴定

外周循环成纤维细胞调控血小板活化参与类风湿关节炎的作用研究

JMJD1c通过Stat3去甲基化抑制B细胞分化延缓干燥综合征发生发展的机制研究

香叶基香叶基焦磷酸盐通过调控RAB35介导的CXCR5膜表达促进系统性红斑狼疮Tfh细胞分化

中性粒细胞来源的PAD4通过介导肠上皮细胞CKMT1瓜氨酸化修饰促进IBD发生发展的机制研究

人源性间充质干细胞外泌体通过Gal3/FcγRⅡ轴调节狼疮骨髓B细胞的机制研究

Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

Integrative spatial analysis reveals aberrant cellular niches driving renal injury in lupus nephritis

角质形成细胞PPARγ缺失导致自发性系统性红斑狼疮的动物模型及其机制研究

芦可替尼通过抑制中性粒细胞活化治疗JAK-STAT通路基因突变的难治性巨噬细胞活化综合征

Akkermansia muciniphila alleviates Hashimoto's thyroiditis by regulating γδT cells

The role of HMGB1 in Th17 polarization and lupus pathogenesis

1型糖尿病中KIR2DL5+CD8+T细胞激活并利用膳食脂质增强其免疫抑制功能

PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

VSIG2 as a Potential Target for Immunotherapy in Autoimmune Diseases

微生态与免疫屏障在特应性皮炎中的作用探索

神经递质多巴胺在肺脏炎症及肿瘤中的免疫调节作用

Emphysema Drives Divergent γδ T Cell Differentiation into Tissue-Regulatory and Type-3 Phenotypes

The multi-organ landscape of B cells highlights dysregulated memory B cell responses in Crohn’s disease

ILC3s通过RANK信号通路调控肠道Tuft细胞增生和2型免疫应答

角质形成细胞的唾液酸化IgG(SIA-IgG)是一种潜在的细胞骨架相关蛋白

NPM1调节ILC3细胞线粒体氧化磷酸化缓解炎症性肠病及肠癌的进展

IL-1β mediated fibroblast-neutrophil crosstalk promotes inflammatory environment in skin lesions of Systemic Lupus Erythematosus

Intestinal epithelial TLR4 deficiency promotes circulating TMAO production that augments systemic Th2 response during atopic dermatitis development

IL-17D-induced metabolic reprogramming empowers the inflammatory memory of keratinocytes to reignite skin inflammation

Patient-derived appendix organoids reveal MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis

ILC3 通过调控肠道黏液蛋白糖基化修饰水平影响肠道菌群对病原菌的抵抗

二型固有淋巴细胞分泌HMGB1-脂滴复合物促进气道中性粒细胞浸润

Neutrophils in Nasal Polyps Exhibit Transcriptional Adaptation and Proinflammatory Role Depend on Local Polyp Milieu

The mechanism of RIPK1 S331 O-GlcNAc glycosylation mediated by O-GlcNAc transferase to promote keratinocyte necroptosis in the pathogenesis of severe drug eruption

TNF-α反馈调控VISTA和Treg介导氨苯砜特异性T细胞应答的机制研究

《医学免疫学》(第八版）课程内容调整和讲授思路探讨

医学免疫学“六结合”进行课程思政案例设计的实践与探索

“求同存异，以交促教”留学生《医学免疫学》课程体系教学探索与研究

免疫学专业研究生课程改革的探索与实践

医学免疫学“五位一体”复合型 人才培养新模式与教学实践

基于AI的免疫学智慧课程构建研究

基础医学课程在培养医学生创新能力中的作用：以机体防御与免疫课程为例

医学免疫学教学数字化新范式——实景数伴实验

高质量开展医学专业基础课程教育教学研究的策略与思考 ---以《免疫学基础与病原生物学》为例

“BOPPPS模型+思维导图”在医学免疫学课程教学中的应用研究

大思政视野下科普融入在《医学免疫学》课程教学与思政教育同向同行协同育人中的探索与实践

以中国传统文化为视角的医学免疫学课程思政教学设计

RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress auto-inflammation

Toll样受体转运调节在核酸固有免疫识别和自身免疫病进程中的作用机制

hnRNPA2B1感知细胞核内腺嘌呤促进IL-1抗细菌天然免疫应答

单细胞转录组解析极端长寿老人独特的免疫特征及成因

cGAS激活引起的内皮细胞和T细胞的相互作用触发三级淋巴组织的形成

病毒通过靶向FPN1破坏宿主限铁机制实现自身免疫逃逸

Microbiota maintains microinflammatory homeostasis through low-doses of lipopolysaccharide to promote the osteogenic effect of neutrophils

African swine fever virus pB318L negatively regulates inflammatory responses by inhibiting the K63 ubiquitination of NEMO and the oligomerization of NLRP3

非B细胞来源游离Igκ型轻链的功能研究

PD-1H (VISTA) expression is dependent on cell interactions and regulates the functionality of CD8+ T cells

趋化因子受体CXCR4激活的结构基础

揭示免疫受体的隐藏世界——完整免疫受体结构的启示

CMTM3 suppresses TGF-β-mediated myofibroblastic activation of macrophages via disrupting the dimerization of TβRI and TβRII.

Stub1 promotes chaperone-mediated autophagic degradation of TBK1 to modulate the host immune responses

CXCL4 and its variant CXCL4L1 activate TLR4 signaling to induce inflammation

The CCL8 secreted by alveolar type II epithelial cells drives the development of asthma

Zika Virus NS5 Protein Inhibits Type I Interferon Signaling via ZSWIM8-CRL3 ubiquitin Ligase-Mediated Degradation of STAT2

呼吸道病毒感染的炎症诱导及调控机制

Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV

Upregulation of TIGIT regulates the differentiation and metabolic function of CD4+ T cells in Echinococcus multilocularis infection mouse model

嘌呤核苷酸磷酸化酶（PNP）：一种新型抗流感病毒的宿主靶标

III型干扰素在抗病毒感染和致病中发挥底层“保命”的关键作用

The immune dysfunction of maternal-fetal interface mediated by respiratory virus infection

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS to induce immunosuppression

A “suicide” BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

Development of a Nidogen 1 mRNA-LNP Vaccine and its application in liver cancer treatment

DNA vaccines encoding HTNV GP-derived Th epitopes benefited from a LAMP-targeting strategy and established cellular immunoprotection

Immunological characteristics of a recombinant alphaherpesvirus with an envelope-embedded Cap protein of circovirus

基于丝素蛋白修饰的纳米MOF增强HBsAg热稳定性和免疫原性的机制研究

Immunodominance of epitopes and protection efficacy of FimA of Klebsiella pneumoniae are differentially altered by different adjuvants

Development of T follicular helper cell-independent nanoparticle vaccines for SARS-CoV-2 by targeting ICOSL

靶向M细胞的多房棘球绦虫重组乳酸菌LL-plSAM-GILE的构建与免疫保护作用研究

肿瘤免疫治疗联合药物预测及相关生物信息工具

Epigenetic Therapy Sensitizes HER2/ErbB2 Targeted Intervention via Z-RNA/ZBP1-driven Tumor Immunogenicity

Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

The gut microbiota metabolite deoxycholic acid shapes the tumor immune-suppressive microenvironment and promotes breast cancer progression

Loss of Annexin-A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway

Gastric cancer stem cell reprogramming of arginine metabolism escapes tumour killing ability of NK cells

CBX4表观修饰抑制内源性逆转录元件促进免疫逃逸

Sialidase NEU4 tunings the function of CD166 for facilitating the immune evasion of ovarian cancer

甲状腺癌免疫微环境的研究

MFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1

Macrophage-derived FN1 promotes NSCLC progression by autophagy-mediated immunosuppression and ECM stiffening

EDIL3+ CAF通过破坏淋巴内皮细胞屏障作用促进乳腺癌淋巴结转移

延胡索酸促进NR4A1转录诱导ILC1细胞免疫耗竭加速肝癌进展的机制研究

Cancer cells transfer Tmem176b to suppress T cell early activation and drive immune evasion

RGS14 Orchestrates β-Catenin Activation and IL-6-Dependent M2 Macrophage Polarization to Drive Pre-Metastatic Niche Formation and Liver Metastasis in Radioresistant Colorectal Cancer

Social isolation promotes tumor immune evasion by sympathetic nerve excitation

CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis

Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors

The exogenous non-proteinogenic amino acid BMAA-based vaccine induces the immune responses against colorectal cancer

肿瘤细胞来源的唾液酸化IgG(SIA-IgG)通过增强糖酵解促进三阴性乳腺癌发生发展

Neoleukin-2/15-expressing CAR-NK cells resist immunosuppressive polarization in solid tumors to sustain superior therapeutic efficacy

Immune checkpoint blockade is synergized by macrophage-driven tertiary lymphoid structures

Safety assessment of biologics in the BRGSF-HIS: a highly predictive and translational mouse model

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Humanized Dual-Targeting Antibody-Drug Conjugates Specific to MET and RON Receptors as a Pharmaceutical Strategy for Treatment of Cancers Exhibiting Phenotypic Heterogeneity

原位递送 Gasdermin E mRNA通过肌酸引发Ⅰ型干扰素信号促进抗肿瘤免疫应答

An epithelium/imcDC2 axis facilitates the resistance of neoadjuvant anti-PD-1 in human NSCLC

Targeted Clearance of Senescent Cells via Engineered Extracellular Vesicles Reprograms Tumor Immunosuppressive Microenvironment

CD94 deficiency or blockade unleashes the anti-tumor immunity in mice and humanized murine models

SLAMF7 Enhances Double Negative T cells Anti-tumor Function through Upregulating Glutamine Metabolism

Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations

A Biomimetic Nanoplatform for Modulating the Tumor Microenvironment and Countering Tumor Relapse and Metastasis Followed Photothermal Therapy

Breaking new ground: discoveries in the pathogenesis of major autoimmune diseases

METTL3调控CIA小鼠MDSC功能变化的实验研究

Targeting senescent B cells to treat Systemic Lupus Erythematosus

工程化肽-寡核苷酸共轭纳米递送体系的构建及在类风湿性关节炎中的作用与机制研究

磷酸酶PHLPP1表观控制肺泡巨噬细胞的促纤维化反应保护肺纤维化

肺泡上皮细胞转化中间态参与系统性硬化症肺纤维化的作用及机制研究

衰老Tfh细胞在系统性红斑狼疮B细胞异常活化中的作用及机制探索

Lactylation of IgA1 Heavy Chain Contribute to Immune Complex Formation in IgA Nephropathy

Comprehensive immunoprofiling of periphery blood identifies key immune features associated with disease progression and patient stratification of SLE

All-trans Retinoic Acid emerges potential in immune homeostasis for Rheumatoid Arthritis by improving Treg function and stability

CXCR5+ Myeloid-Derived Suppressor Cells Drive B Cell Mediated Immune Response In Primary Sjögren’s Syndrome

Downregulation of DRP1 Promoted Rheumatoid Arthritis CD4+PD-1+T Cell Senescence by Regulating Mitochondrial Function

Critical role of G protein-coupled receptor 40 in B cell response and the pathogenesis of rheumatoid arthritis in mice and patients

Calpain 15 restrains cGAS activity to ameliorate pathogenetic process of rheumatoid arthritis

RNA聚合酶抑制剂CX5461在自身免疫疾病中的疗效及机制研究

Repression of the Aryl-hydrocarbon Receptor Prevents Oxidative Stress and Ferroptosis of Intestinal γδT cells and Alleviates Systemic Lupus Erythematosus

Three active ingredients of Dahuang Mudan decoction target ILC3 via different mechanisms to repair the impaired intestinal mucosal barrier in UC

NRP-1 Receptor-Mediated Targeted Regulation of Pulmonary Vascular Endothelial Cells with Natural Agents for PAH Treatment

Mechanistic Insights into Ovarian Cancer Suppression: Calycosin and Bisdemethoxycurcumin Synergistically Targeting the MCM2 Gene

Jing-Yin-Gu-Biao Formula protects against postinfluenza bacterial coinfection by inhibiting neutrophil extracellular traps formation and regulating gut-lung axis

Sishen Pill treats chronic ulcerative colitis by regulating CD4+CD73+ memory Th17 cell metabolism

Lizhong Decoction Restores Treg/Th17 Balance by Inducing MDSC Accumulation to Mitigate Necrotizing Enterocolitis

Intestinal IL-17A regulates gut microbiota-mediated histone deacetylation and promotes Treg differentiation to mediate the alleviation of asthma by Ma-Xing-Shi-Gan decoction

Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8+ effector T cells in hepatocellular carcinoma

Nonadditive transcriptional change analysis identifies NF-κB and IRF3 as regulators for ginsenoside Rg3 to alleviate synergistic cytokine production in TLR2/3 dual-stimulated macrophages

益气除痰方干预 COX-2/PGE2 信号抑制肿瘤相关中性粒细胞的抗肺癌机制

PD-1 inhibit CD4+ TRMs mediated cDC1-mobilization via suppressing JAML in human NSCLC

Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion

tRNA衍生片段3 ' tRF-Ala-CGC通过调节NK细胞配体MICA表达影响结直肠癌中NK细胞免疫应答

靶向肿瘤细胞内NAT10通过激活I型干扰素信号通路促进抗肿瘤免疫应答

ERMAP、galectin-9和dectin-2的结合促进Kupffer细胞吞噬作用和抗肿瘤免疫

Aspirin prevents colorectal cancer by regulating the abundance of Enterococcus cecorum and TIGIT+Treg cells

Extramedullary neutrophil generation in lung promotes stroke-associated pneumonia

Maternal NK cells under prenatal stress aberrantly drive the neuroimmune disorders in offspring

The mechanism and significance of PDGFB contributes to renal macrophages in regulating sympathetic nerve activity and water and sodium balance

单细胞多尺度揭示阿尔茨海默症的免疫衰老特征

Neuroinflammation and sympathetic nervous activation in hypertension

Disruption of CD8+ regulatory T cell-mediated suppression of peripheral anti-Aβ autoantibody response ameliorates Alzheimer’s disease

Bi-directional neuro-immune communication regulates host defense against helminth infection

Maternal Immune Activation-Induced Autism-Like Phenotypes and Potential Immunotherapies for Neuropsychiatric Diseases

Reconstituted CD74+ NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation

内质网应激调控老年供肾中三级淋巴结构形成的单细胞联合空间转录组学分析

BHLHE40动态调控组织驻留记忆性T细胞在肾移植排斥反应中的机制研究

Dysregulation of N6-Methyladenosine (m6A) Methylation of Sema4d mRNA Leads to Treg Dysfunction and Allograft Rejection

IKZF2 Regulates the Survival and Function of Double Negative T Cells via Cytosolic One-carbon Metabolism

Distinct Immune Homeostasis Remodeling Patterns after HLA-matched and Haploidentical Transplantation

小胶质细胞介导的神经炎症与疾病

酸刺激通过神经元信号通路减轻巨噬细胞介导的肝损伤

CD8+T细胞动脉瘤形成中作用及其机制

mtDNA通过Notch信号调控M1型巨噬细胞极化加剧结蛋白相关性心肌病中心室重构进展

Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction

Itaconate suppresses atherosclerosis by activating anti-inflammatory response in macrophages

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.

基于抗体微珠微流控芯片的肿瘤液体活检技术研究

Development of a RPA-CRISPR/Cas12a based rapid visual detection assay for Porcine Parvovirus 7

Single-cell analyses reveal unique immune characteristics of malignant pleural effusion

Discovery of a Novel Immunoregulatory Subset: Circulating Siglec9+CD8+ T Cells Restrict Immunotherapy Response in Nasopharyngeal Carcinoma

高通量膜蛋白相互作用筛选新技术——DoubletSeeker

Comprehensive dissection of human cellular immune responses by iCWAS reveals a new NK cell subset in antiviral immunity

活体显微成像观测癌症免疫疗法中小分子药物与免疫细胞相互作用

基于造血岛的新型红细胞人源化小鼠模型的构建与应用

Development of doubly humanized immune system and liver in mouse, a new tool for drug development and safety assessment

基于点击化学的多抗原特异性T细胞功能性筛选和多组学研究

ATP flow：基于流式细胞术的快速活细胞代谢分析方法

STING-Dependent Myeloid-Derived Suppressor Cells Expansion and Osteoclastogenesis Orchestrate the Immune Microenvironment of Osteoarthritis

免疫细胞功能干预的类病原体纳米药物和策略

Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats

巨噬细胞对肾脏纤维化的调控作用及靶向干预探索

检测癌症患者外周血中广谱肿瘤抗原特异性T细胞含量变化可高效预测癌症免疫治疗疗效

Delicaflavone reactivates anti-tumor immune responses by abrogating monocytic myeloid cell-mediated immunosuppression

TRMT6 mediated tRNA m1A Modifications maintains colonic epithelial cell homeostasis in DSS induced Crohn’s disease

A Bimetallic Nanoplatform Synergistically Amplifies Cuproptosis and cGAS-STING Activation for Enhanced Triple-Negative Breast Cancer Immunotherapy

FBLL1 acts as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

构建百万级跨疾病CD8+ T细胞图谱：克隆状态演变与功能多样性的综合解析

NAT10 promotes endothelial ferroptosis through increasing the ac4C modification of HMOX1 in Deep vein thrombosis

SARS-CoV-2 NP的泛MHC-I类优势表位免疫学特性评价与验证

The nuclear RBP4 reshapes the adipose-rich microenvironment for the omentum metastasis of ovarian cancer

Ⅰ和Ⅱ型菌毛介导肺炎链球菌经不同内吞途径侵入血脑屏障细胞机制

基于新型多模态分子影像技术的免疫检查点分子在体无创定量可视化及指导免疫治疗研究

Targeting S100A8/A9 to regulate manganese homeostasis in ulcerative colitis